Nano Bugle

A window into applied science supported by INL

New Generation of Orthopaedic, Dental And Cardiovascular Prostheses

Image obtained from

Image obtained from

A research conducted by scientists from the Université de Montréal in collaboration with McGill University, the Institut National de la Recherche Scientifique (INRS-EMT), Plasmionique Inc. and the University of São Paulo, could provide a breakthrough in the field of medical implants.

A major concern in the introduction of prostheses is the possibility of a body rejection. The research mentioned above could mean a breakthrough in finding a solution to this problem through application of advances in nanotechnology.

According to the authors, with the use of chemical modifications it is possible to produce intelligent metal surfaces metals that will help the cells to control their biological response facilitating healing. During the investigation, they have used chemicals to modify the surface of metals used commonly in biomedicine, such as titanium. It is possible to obtain sponge-like patterns with areas of nano pits exposing these metals to selected etching mixtures of acids and oxidants.

The study analyzed the influence of nanoporos produced on the surface of titanium on the growth and cell development, showing that these surfaces promote the growth of bone cells, and reduce the growth of unwanted cells and stimulated stem cells.

The uncontrolled growth of these cells represents a problem on their interaction between the metal surfaces, as they may interfere with blood flow when used in cardiovascular stands or form capsules around dental implants –used for this purpose causing them to fail. However, the authors argue that with subtle changes in chemical composition of the etching mixtures it is possible to control the nanopatrones created in the metal surface and thereby control cellular responses.

This development could influence positively to the successful implementation of orthopaedic, dental and cardiovascular prostheses eliminating side effects and the need for drugs, and making the implants work actively with the biological environment in the healing process.


February 20, 2009 - Posted by | Nanomedicine

1 Comment »

  1. This is promising stuff! Technology has come such a long way.

    Comment by Nutrition | July 12, 2010 | Reply

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